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Forty patients with diffuse large cell lymphoma relapsed after or refractory to first-line therapy were treated with high-dose IV melphalan and recombinant human granulocyte colony-stimulating factor (G-CSF) (CB-08 in 12 patients and G-CSF alone in 28) in an ongoing phase I/II study. A total of 5/12 (41%) and 2/28 (7%) complete responses were observed in the CB-08 and G-CSF arm, respectively (p=0.004). Grade 3/4 and 4/5 bone marrow toxicity were less frequent in the G-CSF group (17 and 14%, respectively) than in the CB-08 group (45 and 50%, respectively) (p=0.001). In the 11 patients that required support of their neutrophil recovery, the median time for neutrophil recovery was 15 days with G-CSF and 49 days with CB-08 (p=0.0004). Median survival in the G-CSF group was 13 months compared to 8 months in the CB-08 group (log-rank test p=0.003). In summary, this combination was associated with durable complete remissions in 40% of patients with high-risk diffuse large cell lymphoma.Causes and consequences of education system related delays in health care seeking for patients with acute abdominal pain.
Studies have shown that only a minority of people with acute abdominal pain report early to a doctor. The main purpose of this study was to describe the pathways through which school teachers, parents and other community members contribute to education system related delays in health care seeking for patients with abdominal pain. The data were collected through four focus groups with 14 participants, a telephone interview, and a survey. Two hundred and eleven participants were asked to describe the causes and consequences of these delays. Delay in school teachers was perceived to be related to the following factors: (i) the learning process in school, (ii) participants’ knowledge and fear of the teachers’ behaviour, (iii) low motivation to search for medical help, (iv) excessive worry about the student’s health,